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How Spatial Cues Support Communication: Interactions Between Auditory Spatial Features and Task Demands Across Cortical Networks

Status: Recruiting
Location: See location...
Intervention Type: Other, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Understanding speech in restaurants and other noisy environments is the most common complaint from the more than 60 million Americans with hearing impairment. Succeeding in such environments requires a listener to first segregate sound sources and then selectively attend to the source of interest. This study examines how individual auditory spatial cues (interaural time differences and interaural level differences) support spatial selective attention, the cortical processes that underlie this ability, and how these processes are modulated by task demands. Participants with normal hearing and participants who use bilateral cochlear implants will perform listening tasks while brain and physiological responses are recorded (electroencephalography, functional near-infrared spectroscopy, pupillometry, and, for normal-hearing participants only, functional magnetic resonance imaging). The findings will provide new insights into the mechanisms of spatial selective attention and help guide clinical solutions for cochlear implant users, individuals with hearing impairment more generally, and older normal-hearing adults who have difficulty understanding speech in noisy environments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: t
View:

• Adults with normal hearing, confirmed by audiometric assessment (thresholds within 20 dB HL of normal through 8 kHz), OR adults with bilateral cochlear implants who have used their implants for at least one year

• Native speakers of American English

• Normal or corrected-to-normal vision

Locations
United States
Florida
University of South Florida, PCD Building, Room 3008A
RECRUITING
Tampa
Contact Information
Primary
Christopher A Brown, PhD
cb43@usf.edu
412-670-2772
Time Frame
Start Date: 2025-10-22
Estimated Completion Date: 2030-07
Participants
Target number of participants: 80
Treatments
Other: Bilateral Cochlear Implant Users
Adults with existing bilateral cochlear implants (implanted and using their devices for at least one year). Participants complete the discrimination and selective-attention auditory paradigms with manipulated spatial cues while combined EEG, fNIRS, and pupillometry are recorded. No fMRI is collected in this arm due to device safety concerns.
Other: Normal Hearing Controls
Adults with audiometrically confirmed normal hearing (thresholds within 20 dB HL of normal through 8 kHz). Participants complete three auditory attention paradigms (working memory, discrimination, selective attention) with manipulated spatial cues, under combined EEG, fNIRS, and pupillometry sessions and fMRI sessions.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD), Carnegie Mellon University
Leads: University of South Florida

This content was sourced from clinicaltrials.gov