Change in Brain Perfusion During Induction of General Anesthesia: Relationship Between Transcranial Doppler, Bispectral Index and Cerebral Oximetry : a Prospective Observational Study CERVO2

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality. Furthermore, arterial hypotension may also decrease cerebral perfusion contributing to worsen neurological outcome. It seems necessary to monitor cerebral perfusion during anesthesia and to define individual dynamic targets of blood pressure. The goal of this study is to evaluate cerebral perfusion change in adult patients with or without cardiovascular risk factors during a standardized propofol-remifentanil anesthesia induction. Cerebral perfusion will be evaluated and compared by simultaneous measurements of cerebral blood flow, cerebral oxygen saturation and neurological function with use of transcranial Doppler (TCD), Near infrared spectroscopy (NIRS) and the Bispectral index (BIS) monitoring, respectively. Those measurements will be also repeated during and after treatment of arterial hypotension episodes in both groups.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Major patients (≥ 18 years old)

• Eligible for an interventional radiology procedure or orthopedic surgery under general anesthesia.

• Patients who expressed their non-opposition to participation in this research

Locations
Other Locations
France
AP-HP, Lariboisière Hospital, Department of Anesthesiology and Intensive Care
RECRUITING
Paris
Contact Information
Primary
Joaquim MATEO, MD
joaquim.mateo@aphp.fr
+33 (0)1 49 95 83 74
Backup
Fabrice VALLEE, MD
fabrice.vallee@gmail.com
+33 (0)1 49 95 80 71
Time Frame
Start Date: 2021-01-27
Estimated Completion Date: 2024-01
Participants
Target number of participants: 101
Treatments
Interventional radiology or surgery under general anesthesia
Monitoring of patients (mean arterial blood pressure, Transcranial Doppler , bispectral index, near infrared spectroscopy) who benefit from intraoperative hemodynamic optimization with norepinephrine (as noradrenaline tartrate) for maintaining blood pressure under general anaesthesia during the interventional neuroradiology or orthopedic surgery in adults .
Related Therapeutic Areas
Sponsors
Collaborators: LMS Ecole polytechnique, INSERM UMR-942, Paris, France, M3DISIM Inria Université Paris-Saclay
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov

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