SONOthrombolysis in Patients With an ST-segment Elevation Myocardial Infarction With fibrinoLYSIS (SONOSTEMI-LYSIS) Trial
Who is this study for? Patients with Myocardial Infarction
What treatments are being studied? Definity® with High Mechanical Index Ultrasound
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
This study will assess the safety and feasibility of sonothrombolysis in the acute management of STEMI undergoing reperfusion therapy with systemic fibrinolysis as part of a pharmacoinvasive approach
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients presenting with STEMI within 6 hours of symptom onset and:
‣ Are expected to receive reperfusion therapy with fibrinolysis
⁃ Have a high-risk STEMI ECG as defined as:
• \>2mm ST-segment elevation in 2 anterior or lateral leads; or
∙ \>2mm ST-segment elevation in 2 inferior leads coupled with ST-segment depression in 2 contiguous anterior leads for a total ST-segment deviation of \>4mm
⁃ Age \>30 years
⁃ Adequate apical and/or parasternal images by echocardiography
Locations
Other Locations
Canada
University of Alberta
RECRUITING
Edmonton
Time Frame
Start Date: 2021-02-23
Estimated Completion Date: 2026-05-01
Participants
Target number of participants: 60
Treatments
Experimental: Sonothrombolysis
Diagnostic myocardial contrast echocardiography with ultrasound contrast agent 5% Definity® plus Sonothrombolysis
No_intervention: Standard of Care
Diagnostic myocardial contrast echocardiography with ultrasound contrast agent 5% Definity®
Related Therapeutic Areas
Sponsors
Collaborators: Canadian VIGOUR Centre
Leads: University of Alberta