the Association of Intestinal Microbial Metabolites and Cardiac Function in Acute Myocardial Infarction
Recently, more and more studies have confirmed that intestinal flora is closely related to the occurrence and development of cardiovascular diseases.Bile acids (BAS), short chain fatty acids (SCFA) and trimethylamine oxide (TMAO), the main metabolites of intestinal flora, are the key mediators of the interaction between gut and host. We aim to explore the association of BAs and SCFA with cardiac function in patients with AMI.
⁃ The patient, aged 18-85 years, had undergone coronary angiography and agreed to be enrolled and signed the informed consent.
⁃ AMI : according to ST segment elevation myocardial infarction diagnostic criteria.
⁃ UAP:
• typical chest pain symptoms;
• negative in markers of myocardial injury;
• The stenosis of main coronary artery or its main branches is more than 50%
⁃ Control:
• atypical chest pain symptoms
• negative in markers of myocardial injury;
• The stenosis of main coronary artery and its main branches is less than 50%