Optical Coherence Tomography With Magnetic Resonance Angiography to Assess STEMI Non-culprit Risk

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time. Although in general people do better if these non-culprit narrowings are also treated with stents if they look severe, this process has problems. This is because narrowings that look severe may be stable and not cause any trouble. For these people a stent is a wasted procedure and unnecessary risk. On the other hand, narrowings that are currently left alone because they appear mild, may progress and cause a heart attack. Participants who have had a heart attack will have a scan from inside the heart arteries during an angiogram (optical coherence tomography, OCT) and a magnetic resonance angiogram (MRA). If the investigators can show that it is possible to accurately predict which non-culprit narrowings are going to progress and which are going to stabilise, medical professionals may be able to better target their treatments after a heart attack.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Successful primary percutaneous coronary intervention (PCI) within the previous week with no major complications at the index procedure

• Bystander disease in a non-culprit vessel planned for clinically indicated staged angiography +/- PCI

• Able to provide written informed consent.

Locations
Other Locations
United Kingdom
King's College Hospital
RECRUITING
London
St Thomas' Hospital
RECRUITING
London
Contact Information
Primary
Matthew Li Kam Wa, MBBS
mlikamwa@nhs.net
02071887188
Time Frame
Start Date: 2023-04-25
Estimated Completion Date: 2028-04
Participants
Target number of participants: 90
Treatments
Standard of care
Patients after ST-elevation myocardial infarction with non-culprit coronary artery disease.
Related Therapeutic Areas
Sponsors
Collaborators: King's College Hospital NHS Trust, King's College London
Leads: Guy's and St Thomas' NHS Foundation Trust

This content was sourced from clinicaltrials.gov