Initial CT Perfusion-Guided Strategy Versus Invasive Coronary Angiography in Patients With Suspected Non-ST-Segment Elevation Myocardial Infarction

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Diagnostic test, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Non-ST elevation myocardial infarction (NSTEMI) is a relatively complex type of myocardial infarction, characterized by chest pain symptoms and elevated troponin levels. However, some patients initially diagnosed with suspected NSTEMI are found not to have severe stenosis upon coronary angiography. Recent studies have shown that initial imaging examinations (including CTA and CMR) in suspected NSTEMI patients can help reduce the need for coronary angiography. The diagnostic value of CT perfusion (CTP) has been established in patients with stable coronary artery disease, but relevant studies have not yet been conducted in suspected NSTEMI patients. This study aims to explore the diagnostic and therapeutic value of an initial CTP strategy for suspected NSTEMI patients. Additionally, we will conduct a cardiovascular health questionnaire to investigate the impact and prognostic value of factors such as adverse lifestyle and inflammation levels in these patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients with stable chest tightness or chest pain, aged ≥18 years

• No ST elevation or dynamic ST-T changes on the ECG

• Elevated TNT (greater than 14 ng/L three hours after symptom onset)

Locations
Other Locations
China
Zhongshan Hospital Fudan University
RECRUITING
Shanghai
Zhongshan Hospital Fudan University
NOT_YET_RECRUITING
Shanghai
Contact Information
Primary
Wei Gao, PhD
gao.wei1@zs-hospital.sh.cn
86-13661959824
Backup
Yan Xia, PhD
xia.yan@zs-hospital.sh.cn
Time Frame
Start Date: 2024-12-01
Estimated Completion Date: 2026-02-28
Participants
Target number of participants: 100
Treatments
Experimental: Initial CT perfusion
Patients enrolled in the Initial CT perfusion group will first undergo CTA and CTP examinations. Based on the results of these tests, the treatment team will then decide whether to proceed with conservative medical therapy or perform coronary angiography.
Active_comparator: Invasive Coronary Angiography
Patients enrolled in the Invasive Coronary Angiography group will directly undergo coronary angiography. If necessary, intracoronary imaging (including IVUS and OCT) will be performed. Based on the results of these tests, the treatment team will then decide whether to proceed with conservative medical therapy or interventional treatment (including stent implantation or balloon angioplasty).
Related Therapeutic Areas
Sponsors
Leads: Shanghai Zhongshan Hospital

This content was sourced from clinicaltrials.gov