Prediction of Left Ventricular Adverse Remodeling and Major Adverse Cardiovascular Events in Patients With Acute ST-segment Elevation Myocardial Infarction Though Plasma Multiomics Analysis
To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction, and to investigate the molecular pathways linked to LVAR and MACE.
• Age ≥18 years and ≤80 years.
• Definite diagnosis of STEMI according to ESC/ACC guidelines:
‣ Chest pain lasting \>30 minutes, and
⁃ ST-segment elevation in at least two contiguous leads: ≥0.2 mV in leads V2-V3 (≥0.2 mV for men, ≥0.15 mV for women) or ≥0.1 mV in other leads, or new-onset left bundle branch block.
• Reperfusion therapy: Symptom onset to first medical contact ≤12 hours, and successful primary PCI (culprit vessel opened, post-procedure TIMI flow grade 3).
• First STEMI (no prior history of myocardial infarction).
• Left ventricular ejection fraction (by echocardiography within 24-48 hours after admission) ≥35%.
• Informed consent: Signed informed consent obtained, with willingness to undergo serial blood sampling and echocardiographic follow-up.