Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions this study aims to answer are: 1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age 18 years and over

• Primary presentation with symptoms related to atrial fibrillation

• Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram

• Able to provide informed consent

Locations
Other Locations
United Kingdom
Royal Infirmary of Edinburgh
RECRUITING
Edinburgh
Time Frame
Start Date: 2025-05-01
Estimated Completion Date: 2029-10
Participants
Target number of participants: 300
Sponsors
Collaborators: British Heart Foundation, NHS Lothian
Leads: University of Edinburgh

This content was sourced from clinicaltrials.gov