Heart Failure Clinical Trials

• Diagnosed with cardiac, respiratory or cardiorespiratory failure or imminent failure and 1 of the 5 following sets of findings:

‣ A Murray score ≥ 3.0 and/or severe hypoxemia with A PaO2/FIO2 \> 100 mm on 0.9 FIO2;

⁃ Uncompensated hypercapnia with pH \<7.2 despite a Pplateau \> 30 cm H20;

⁃ Significant air leak/bronchopleural fistula;

⁃ Need for intubation in a patient on lung transplant list;

⁃ Immediate/risk of cardiac or respiratory collapse (pulmonary embolus, blocked airway, blocked blood flow, unresponsive to optimal care);

• Written consent of the patient or the legal guardian or external consulting physician as designated and approved by the Ethics Committee.