Effectiveness of Indoor Air Purifiers on Heart Failure Outcomes

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Indoor air pollution and fine mode particulate matter with an aerodynamic diameter smaller than 2.5 micrometers (PM2.5) is a major contributor to global morbidity and mortality, particularly due to cardiovascular disease. This project aims to demonstrate the efficacy, feasibility and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India. The findings from the project will add to existing knowledge of innovative and scalable strategies to improve environmental and cardiovascular health worldwide. The overall objective of this study is to demonstrate the efficacy, feasibility, and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adults ≥ 18 years of age diagnosed with HF with a reduced ejection fraction of ≤ 40% within the last six months in NYHA class II-IV.

Locations
Other Locations
India
All India Institute of Medical Sciences (AIIMS)
RECRUITING
Delhi
Public Health Foundation of India (PHFI)
RECRUITING
Ludhiana
Centre for Chronic Disease Control (CCDC)
RECRUITING
Thiruvananthapuram
Contact Information
Primary
Rajesh Vedanthan, MD, MPH
Rajesh.vedanthan@nyulangone.org
646-501-3890
Backup
Jessica Gjonaj
Jessica.gjonaj@nyulangone.org
646-501-3663
Time Frame
Start Date: 2024-03-06
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 600
Treatments
Experimental: HEPA Air Purifier
Air purifier is installed in participants' households by the research team. Twice per year, participants will wear a GPS as well as a backpack containing a particulate matter 2.5 (PM2.5) personal exposure monitor for a 24-hour monitoring period.
Placebo_comparator: EGAPA Air Purifier
Air purifier is installed in participants' households by the research team. Twice per year, participants will wear a GPS as well as a backpack containing a particulate matter 2.5 (PM2.5) personal exposure monitor for a 24-hour monitoring period.
Related Therapeutic Areas
Sponsors
Leads: NYU Langone Health
Collaborators: National Institute of Environmental Health Sciences (NIEHS)

This content was sourced from clinicaltrials.gov