Effect of Nicotinamide Riboside on Myocardial and Skeletal Muscle Injury and Function in Patients With Metastatic Breast Cancer Receiving Anthracyclines
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
Breast cancer is the most common form of cancer in women. Modern breast cancer treatments have led to increased survival, but at the same time, increased risk for cardiotoxicity and development of heart failure. In this study, the investigators want to evaluate whether nicotinamide riboside can prevent cancer-related cardiac dysfunction in metastatic breast cancer patients scheduled for anthracycline therapy. Further, the investigators will evaluate change in signs of skeletal muscle injury and functional capacity.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
• Women with metastatic breast cancer (stage IV breast cancer) scheduled for anthracycline-containing chemotherapy
• Eastern Cooperative Oncology Group performance status 0-2
Locations
Other Locations
Norway
Akershus University Hospital
RECRUITING
Lørenskog
Contact Information
Primary
Torbjørn Omland, MD, PhD
torbjorn.omland@medisin.uio.no
+47 40107050
Backup
Victoria Vinje, MD
victoria.vinje@ahus.no
+47 92033665
Time Frame
Start Date: 2023-03-16
Estimated Completion Date: 2035-09-30
Participants
Target number of participants: 60
Treatments
Active_comparator: Treatment Arm
The patients randomised into this arm of the trial will receive 500 mg Nicotinamide Riboside b.i.d. The duration of blinded therapy will depend on the duration of anthracycline therapy, and will for some patients last for 3 months, others for 6 months.
Placebo_comparator: Placebo Control Arm
The patients randomised into this arm of the trial will receive a matching placebo b.i.d. The duration of treatment is equivalent to the description in the treatment arm.
Related Therapeutic Areas
Sponsors
Collaborators: ChromaDex, Inc., Norwegian Breast Cancer Association, Helse Sor-Ost, Norwegian Cancer Society
Leads: University Hospital, Akershus