Valutazione Ecocardiografica Della Riserva Contrattile Del Ventricolo Destro Dopo Carico Volemico Acuto Mediante Sollevamento Passivo Delle Gambe e Durante Infusione di Dobutamina in Pazienti Affetti da Scompenso Cardiaco a Frazione d'Eiezione Ridotta (HFrEF) e Preservata (HFpEF)

Status: Recruiting
Location: See location...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Right ventricle dysfunction and pulmonary hypertension are related to a worse prognosis in patients with heart failure with reduced left ventricular ejection fraction (HFrEF) or with normal left ventricular ejection fraction (HFpEF). There is preliminary evidence however, that the responses of the right ventricle and of the pulmonary hemodynamics to stress tests (especially physical stress) may allow to prognostically stratify these patients, as these responses may bring out latent right ventricle dysfunction or a normal contractile reserve in patients with dysfunction at rest. In view of the different pathophysiological mechanisms of the left ventricular dysfunction in HFpEF and in HFrEF, also the response and the adaptation of the righty ventricle to stress tests may be different in these two groups of patients. In this preliminary two groups of 20 patients with HFpEF and HFrEF will be subjected to to simple stress tests: passive leg raising and inotropic stimulus with dobutamine. This study intends to analyze, through colorDoppler echocardiography, the behaviour of the right ventricle and the pulmonary circulation during passive leg raining and infusion of dobutamine, in a cohort of patients with HFrEF or HFpEF. The analysis will be focused on the relation between echocardiographic parameters, especially those concerning right ventricular function and pulmonary hemodynamics, thereby comparing the responses observed in HFrEF vs HFpEF. Furthermore, correlations between the above-mentioned echocardiographic parameters and parameters of daily clinical practice will be assessed.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:

• heart failure with reduced (EF ≤40%) or preserved (EF \> 50%) ejection fraction

• echocardiographic acoustic window adequate for evaluation of outcome parameters

• presence of tricuspid insufficiency which allows assessment of pulmonary artery systolic pressure

Locations
Other Locations
Italy
Ospedale San Luca IRCCS Istituto Auxologico Italiano
RECRUITING
Milan
Contact Information
Primary
Sergio Caravita, MD, PhD
s.caravita@auxologico.it
+390261911
Time Frame
Start Date: 2019-03-20
Estimated Completion Date: 2026-03-20
Participants
Target number of participants: 60
Treatments
Other: EchocardiocolorDoppler
EchocardiocolorDoppler examination
Sponsors
Leads: Istituto Auxologico Italiano

This content was sourced from clinicaltrials.gov