Strategy Therapy on Early Phase Cancer Therapeutics-Related Cardiac Dysfunction Patients

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The investigators use the cancer registration system of National Cheng Kung University Hospital to timely screen and evaluate those patients having breast cancer or lymphoma to enroll patients to participate in this clinical trial. The investigators planned an earlier initiation of Sacubitril/Valsartan treatment on breast cancer and lymphoma patients before the chemotherapy, and starting therapeutic intervention by Sacubitril/Valsartan once the heart damage sign appeared via novel echocardiography. The investigators aim to assess the protective and therapeutic benefit of cardioprotective drugs on the cardiotoxicity of anti-cancer therapy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 65
Healthy Volunteers: f
View:

• Patients who are newly diagnosed with breast cancer or lymphoma and never accepted anti-cancer therapy

• Age 20-65 years old

• Systolic blood pressure ≥ 110 mmHg

Locations
Other Locations
Taiwan
National Cheng Kung University Hospital
RECRUITING
Tainan City
Contact Information
Primary
Ping-Yen Liu, PhD.
larry@mail.ncku.edu.tw
+8862353535
Backup
Pei-Tien Hsu
sz2137@yahoo.com.tw
+8862353535
Time Frame
Start Date: 2021-05-05
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 100
Treatments
Experimental: Prevention therapy
Sacubitril/Valsartan (25/80) mg twice a day for 1 year
No_intervention: Conventional therapy
No intervention
No_intervention: Global longitudinal strain (GLS) function decreased >15%, No intervention
With the value of GLS function via echocardiography study decreased \>15%, No intervention
Experimental: GLS function descending >15%, Rescue therapy
Sacubitril/Valsartan (25/80) mg twice a day for 1 year
Related Therapeutic Areas
Sponsors
Leads: National Cheng-Kung University Hospital

This content was sourced from clinicaltrials.gov