A Randomized Controlled Trial of Left Bundle brAnch opTimized Cardiac Resynchronization Therapy Versus conventionaL Bi-vEntricular Pacing in Heart Failure Patients With Nonspecific Intraventricular Conduction Delay
BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment period of 3 years. An LOT-CRT group will be compared with a group of conventional BiVP in the follow-up of at least 6 months. The study aimed to compare the curative effect of LOT-CRT in preserving LV systolic function with traditional BiVP in chronic heart failure patients with NICD.
• Ischemic or non ischemic cardiomyopathy
• Optimal medical therapy for at lest 3 months
• NYHA class II-IV
• LVEF≤35% as assessed by echocardiography
• Sinus rhythm (may have paroxysmal atrial fibrillation)
• QRS duration ≥ 150ms
• Intraventricular block (NICD), QRS morphology is neither LBBB nor RBBB