Registry-based Cardiovascular Quality Improvement Research (RESCUER)

Status: Recruiting
Location: See location...
Intervention Type: Other, Behavioral
Study Type: Observational
SUMMARY

The goal of this registry-based observational study is to establish a comprehensive management plan, which focus on medical therapy, cardiac rehabilitation and active post-market surveillance of medical devices, in patients with cardiovascular diseases (CVD). Patients with CVD mainly refers to four groups of patients:1) post-percutaneous coronary intervention (post-PCI) patients; 2) patients with heart failure (HF); 3) patients with cardiometabolic diseases (CMD); 4) patients with structural heart disease (SHD), and the detailed definition of each group can be found in Eligibility section. The main questions this study aims to answer are: * the effectiveness of exercise-based cardiac rehabilitation in improving cardiac function, reducing CVD recurrence and mortality, and promoting quality of life for patients with CVD; * the feasibility of registry-based active post-market surveillance of high-risk medical devices used in cardiovascular surgeries, such as PCI, heart valve replacement, and cardiac resynchronization therapy (CRT); * the utilization of multiomics datasets to identify and dissect cardiovascular heterogeneity in both healthy and diseased populations and to guide precision medicine in patients with CVD; * the analysis and evaluation of the prescription patterns and drug response in patients with CVD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients aged ≥ 18 years with cardiovascular diseases who are hospitalized at the Department of Cardiology of Peking University Third Hospital after April 24th, 2023;

• Patients meet the following disease definitions:

‣ PCI group: Patients underwent percutaneous coronary intervention (PCI) or coronary angiography;

⁃ HF group: Patients diagnosed with heart failure;

⁃ Cardiometabolic Disease (CMD) group: Patients with cardiovascular disease (primarily including coronary artery disease, peripheral artery disease, and aortic disease) and coexisting metabolic disorder (defined as obesity \[BMI≥28 kg/m\^2\], prediabetes and diabetes, hypertension, hyperlipidemia, thyroid dysfunction, and non-alcoholic fatty liver disease);

⁃ Structural Heart Disease (SHD): Patients with structural heart disease, including

∙ Congenital heart diseases (such as ventricular septal defect, atrial septal defect, patent ductus arteriosus, tetralogy of Fallot, etc.);

• Heart valve diseases (mitral valve, tricuspid valve, aortic valve, pulmonary valve, etc.);

⁃ Cardiomyopathies (hypertrophic cardiomyopathy, dilated cardiomyopathy, etc.);

‣ Conditions associated with other diseases or acquired structural abnormalities of the heart (ventricular septal perforation, ventricular aneurysm, iatrogenic atrial septal defect, etc.);

∙ Conditions resulting from other diseases that cause abnormal heart function, which can be corrected by altering cardiovascular structure (such as left atrial appendage dysfunction caused by atrial fibrillation, abnormal cardiac function caused by heart failure);

• Others: Intracardiac thrombosis, cardiac tumors, pericardial diseases, etc.

Locations
Other Locations
China
Peking University Third Hospital
RECRUITING
Beijing
Contact Information
Primary
Yueyue Xi
18611707034@163.com
18611707034
Time Frame
Start Date: 2023-04-24
Estimated Completion Date: 2026-05
Participants
Target number of participants: 2000
Treatments
PCI group
Patients who received percutaneous coronary intervention (PCI) at the Department of cardiology of Peking University Third Hospital will be included in the PCI group.
Heart failure group
Patients with heart failure who hospitalized at the Department of cardiology of Peking University Third Hospital will be included in the heart failure group.
Cardiometabolic syndrome group
Patients with cardiometabolic syndrome who hospitalized at the Department of cardiology of Peking University Third Hospital will be included in the cardiometabolic syndrome group.
Structural heart disease group
Patients with structural heart disease who hospitalized at the Department of cardiology of Peking University Third Hospital will be included in the structural heart disease group.
Sponsors
Leads: Peking University Third Hospital
Collaborators: Peking University

This content was sourced from clinicaltrials.gov