Cardiac Contractility Modulation (CCM) and Implementation of Guideline-Directed Medical Therapy in Patients With Heart Failure
The primary objective of this study is to evaluate the impact of Cardiac Contractility Modulation (CCM) therapy on the initiation and up-titration of Guideline-Directed Medical Therapy (GDMT) in patients with heart failure (HF). This will be assessed by the change in Quad Medication Score (QMS) from baseline (pre-CCM) to 6-month following post-CCM device implant.
• Adults (≥18 years) diagnosed with symptomatic heart failure
• Patients with Heart failure with reduced Ejection Fraction (HFrEF) where the Ejection Fraction (EF) is ≤40%
• \- Historical LVEF assessed up to 6 months prior to consent by any modality can be used if available
• Patients can have an active concomitant CRT device already - implanted provided the following criteria:
‣ CRT device has been implanted \>1 year
⁃ Patients are functional class NYHA III-IV