Effect of Empagliflozin on Quality of Life in Chronic Heart Failure Patients With Diabetes Mellitus Type II

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

Effect of Empagliflozin on Quality of Life in patient of Chronic Heart Failure with Diabetes Mellitus Type II. As per ESC Guidelines Empagliflozin is recommended as part of the first-line treatment for HFrEF, irrespective of diabetes status. As per American College of Cardiology (ACC)/American Heart Association (AHA) Empagliflozin is recommended in both diabetic and non-diabetic HF (especially beneficial in patients with HFrEF and HFpEF). The aim of my study is to assess the impact of Empagliflozin on quality of life in Pakistani patients, considering the genetic, environmental and cultural factors. The study will also explore whether Empagliflozin can offer cost-effective option for managing chronic heart failure and diabetes, potentially reducing the economic burden on both patients and health care system.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 70
Healthy Volunteers: f
View:

• Age 40-70 years at time of screening.

• Both Men and women are included in study.

• Patients with chronic heart failure and currently categorized in class II-IV heart failure as per NHYA classification having ejection fraction less than 40%.

• Patients having NT- proBNP levels greater than 25pg/ml.

• Diabetic patient diagnosed (HbA1c \> 6.5mg/dl) and currently taking antidiabetic medicine.

Locations
Other Locations
Pakistan
Fazaia Ruth Pfau Hospital
RECRUITING
Karachi
Contact Information
Primary
Tooba Riaz, MBBS
drtoobariaz@outlook.com
03333231665
Backup
DR Asghar Mehdi, MBBS Phd
drasgharmehdi@gmail.com
03008228284
Time Frame
Start Date: 2025-04-01
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 156
Treatments
Experimental: experimental arm, Palcebo controlled group
Experimental arm, taking empagliflozin 10mg once daily along with standard treatment.
Placebo_comparator: Palcebo controlled group
Palcebo controlled group patient receiving placebo to compare with empagliflozin along with standard treatment.
Related Therapeutic Areas
Sponsors
Leads: Fazaia Ruth Pfau Medical College

This content was sourced from clinicaltrials.gov