Liver Infusion Flow Evaluation With ultraSound for Assessment of Right Ventricular Function: a Single cEnter Cohort Study (LIFESAVE)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess ventricular function, they have limitations in terms of accuracy. The pulmonary artery catheter remains the gold standard for assessing RVD. This dysfunction is associated with an increased risk of both renal and hepatic failure, complications that significantly affect patient outcomes. Doppler ultrasound has emerged as a valuable tool in predicting these complications, particularly in monitoring portal circulation and hepatic perfusion. This study aims to explore the association between portal flow pulsatility and RVD after cardiac surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient aged at least 18 years

• Patients undergoing cardiac surgery with cardiopulmonary bypass and presenting at least one risk factor for postoperative complications, including:

‣ Patient over 60 years old

⁃ Preoperative left ventricular ejection fraction (LVEF) \< 50%

⁃ Surgery involving both coronary artery bypass grafting and valve procedures

⁃ Mitral valve surgery

⁃ Preoperative creatinine clearance less than 30 ml/min

• Patient having signed the informed consent form in accordance with regulations

• Patient covered by social security or an equivalent healthcare system

Locations
Other Locations
France
CMC Ambroise Paré Hartmann
RECRUITING
Neuilly-sur-seine
Contact Information
Primary
Lee S Nguyen, MD, PhD
lee.nguyen@clinique-a-pare.fr
0146 418971
Backup
Messaouda MERZOUG, PhD
messaouda.merzoug@clinique-a-pare.fr
Time Frame
Start Date: 2025-02-24
Estimated Completion Date: 2026-10-24
Participants
Target number of participants: 32
Treatments
Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
Measurement of portal flow velocity using transthoracic echography, as well as measurement of the superior vena cava via transesophageal echography for predicting right ventricular dysfunction.
Related Therapeutic Areas
Sponsors
Leads: CMC Ambroise Paré

This content was sourced from clinicaltrials.gov