At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. The main question it aims to answer are * To evaluate the efficacy of an at-home CORE model on short-term cardiovascular fitness and psychosocial wellbeing in adolescent cancer survivors. * To evaluate the exercise adherence rate among adolescents at risk for heart failure and assess barriers to compliance. * To explore which specific CORE resources are of most value to patients in creating sustainable healthy lifestyle modifications. * Hypothesis: Pediatric cancer survivors who implement exercise and dietary recommendations will demonstrate improvement in cardiovascular fitness and general wellness. A multidisciplinary team approach can facilitate adherence to a moderately rigorous exercise prescription, and thus enhance the health benefits of a CORE program at CHLA. Participants will undergo cardiovascular studies and a quality-of-life survey prior to exercise intervention, and at the end of the 6-month study period.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 21
Healthy Volunteers: f
View:

• Patients aged of 10-21 years at enrollment

• Parent/legal guardian available for consent (if applicable), and patient available for assent and consent

• History of anthracycline exposure +/- radiation

• Currently in remission, with at least 6 months off chemotherapy

• Able to perform CPET

• Baseline CPET with VO2 \<80% (at start of study, or CPET at CHLA after January 2020)

• Smartphone compatible with Fitbit (own or parent/legal guardian's)

• Ability to complete and send diary and Fitbit information on a weekly basis

• Ability to participate in monthly virtual check-in visits

• Baseline activity prior to intervention \<30min/day, 2x/week

Locations
United States
California
Children's Hospital Los Angeles
RECRUITING
Los Angeles
Contact Information
Primary
Obdulio Carreras
ocarreras@chla.usc.edu
(323) 361-4663
Backup
Jennifer Su, MD
jsu@chla.usc.edu
(323) 361-5136
Time Frame
Start Date: 2023-10-20
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 20
Treatments
Experimental: Treatment Arm
Related Therapeutic Areas
Sponsors
Leads: Children's Hospital Los Angeles

This content was sourced from clinicaltrials.gov