Eccentric Cycling Exercise During Pulmonary Rehabilitation in Patients With Cardiopulmonary Diseases

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease. Furthermore, we conducted an RCT in which we exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle. The study in patients with PVD was started (EccRehab), and the great potential was recognized. Therefore there was an indication to open the inclusion criteria to all cardiopulmonary patients with indication for pulmonary rehabilitation (EccRehab2). For this purpose, the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with cardiopulmonary diseases.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Diagnosed with PVD, either PAH or CTEPH via right heart catheterization, according to recent guidelines \[9\]

• Diagnosed with a cardiopulmonary disease as indication for a pulmonary rehabilitation

• Stable medication for at least 1 month

• Age 18years to 85 years

• No resting hypoxemia (PaO2 \>7.3 kPa)

• Medical indication to prescibe a pulmonary rehabilitation

Locations
Other Locations
Switzerland
Klinik Barmelweid
RECRUITING
Barmelweid
Universitätsspital Zürich
RECRUITING
Zurich
Contact Information
Primary
Silvia Ulrich, Prof. dr. med.
silvia.ulrich@usz.ch
+41442564362
Backup
Julian Müller, Dr. sc. med.
julian.mueller2@usz.ch
0432539349
Time Frame
Start Date: 2025-05-02
Estimated Completion Date: 2026-05-30
Participants
Target number of participants: 24
Treatments
Experimental: Eccentric cycling
Patients perform eccentric cycling exercise instead of normal cycling exercise in addition to standard car during a cardiopulmonary rehabilitation
Active_comparator: Standard care
Patients perform cardiopulmonary rehabilitation according to standard care
Sponsors
Collaborators: Klinik Barmelweid
Leads: Silvia Ulrich Somaini

This content was sourced from clinicaltrials.gov