The Role of Ultra-high-frequency ECG in the Localization of Left Ventricular Conduction Disorders and Prediction of Response to Resynchronization Therapy

Status: Recruiting
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing approaches based on the assessment of QRS complex morphology and duration from 12-lead ECG. Another goal of the proposed study is to demonstrate that trueLBBB patients will benefit more from CRT using left bundle branch pacing than from CRT using biventricular pacing. The final aim of the project is to demonstrate that the echocardiographic and clinical response in patients with intraventricular conduction disturbance will be dependent on the degree of reduction in ventricular dyssynchrony after CRT.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• HF due to ischemic or non-ischemic cardiomyopathy

• known coronary angiography

• NYHA II-IV

• LVEF ≤40%

• non-RBBB QRSd lasting \>130 ms (by automated measurement)

• proximal LBBB proved by an invasive EP study or non-invasive dyssynchrony assessment in case such a method is confirmed to be non-inferior to an invasive EP study during the project

Contact Information
Primary
Karol Curila, MD
karol.curila@fnkv.cz
+420777869171
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 200
Treatments
Experimental: CSP-CRT arm
In this arm, LBBAP CRT will be performed
Active_comparator: BVP-CRT arm
In this arm, BVP CRT will be performed.
Related Therapeutic Areas
Sponsors
Leads: Faculty Hospital Kralovske Vinohrady

This content was sourced from clinicaltrials.gov