Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
• The study will target adults 18 years of age or older admitted to Lakeland Regional Medical Center who:
‣ Have a primary diagnosis of acute decompensated heart failure, and
⁃ Have at least one of the following signs of hypervolemia:
• Bilateral lower extremity pitting edema
∙ Jugular venous distension
∙ Hepatojugular reflex
∙ Crackles on pulmonary exam, or
∙ Chest x-ray demonstrating pulmonary edema or pleural effusions