Nordic-CSP - a Randomized Nordic Study - Is Conduction System Pacing Superior Compared to Conventional BIV-CRT in Reducing the Death or Heart Failure-related Hospitalization in Patients With Heart Failure and Bundle Branch Block?
The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.
• ≥18 years of age,
• LVEF ≤ 35%,
• NYHA Class II-IV (IV only outpatients),
• optimized in medical treatment (OMT)
⁃ AND one of the following:
⁃ . LBBB according to AHA/ACC/HRS Scientific Statement from 2009 and ≥130ms or
• LBBB-like intraventricular conduction delay (IVCD) \> 150ms or RV paced QRS and indication for upgrade to CRT (\> 40% RV pacing) OR
• ≥18 years of age,
• LVEF ≤ 40 %
• pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing.