Circuity-guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Tobacco Use in Veterans: A Comparison of Insula-rTMS and Prefrontal-rTMS
Cigarette smoking is a significant public health concern for Veterans. Encouraging smoking cessation continues to be a top priority for the Veterans' Administration as Veterans who use tobacco experience negative health effects, including cancer, heart disease, and mental disorders. Despite the efficacy of current evidence-based pharmacotherapies and psychotherapies for smoking cessation, alternative treatments are critically needed. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation, US FDA-approved for smoking cessation. In this protocol, the investigators propose comparing the two rTMS protocols (standard TMS vs. precision TMS) to find a better treatment parameter for smoking cessation in Veterans. Identifying an efficacious rTMS protocol would benefit Veterans who want to quit smoking.
• Veteran
• Individuals who smoke 10 or more cigarettes per day and have a CO level \> 10 ppm indicative of recent smoking
• Those who have not received substance abuse treatment within the previous 30 days
• Those who have been stable on psychotropic medications for at least three months
• For females, those who test non-pregnant and use adequate birth control
• Those who are willing to provide informed consent
• Those who can comply with protocol requirements and likely complete all study procedures
• Those who are motivated to quit smoking (based on responses of very likely or somewhat likely in the motivation questionnaire