Hemochromatosis Clinical Trials

• Adult (≥ 18 years) and has provided written informed consent.

• Confirmed diagnosis of HFE-HH in medical history.

• Evidence of iron overload as shown by:

‣ TSAT \> 45% (confirmed at 2 visits, at least 14 days apart) at Screening; and

⁃ Serum ferritin ≥ 200 nanogram per milliliter (ng/mL) and \< 5000 ng/mL (confirmed at 2 visits, at least 14 days apart) at Screening; and

⁃ MRI-based LIC between 2.4 and 16 mg/g (43.0 and 286.5 mmol/kg) dry weight (dw) at Screening.

• Body mass index between 18.5 and 34.9 kilograms per meter squared (kg/m\^2).