The Immune Responses After Hepatitis B Revaccination Doses in a Young Cohort
This prospective cohort study aims to provide the evidence-based clinical guide to help decide the revaccination doses of hepatitis B vaccine that the high-risk young adults without hepatitis B seroprotective antibodies (anti-HBs titer\<10 mIU/mL) need to take.
• The actual age at the time of admission was higher than 20 years old and birth year after 1987
• Born in Taiwan and had received a full course of hepatitis B vaccines at least three doses at infant period.
• Those who have tested negative for hepatitis B surface antibody and surface antigen at baseline
• Have never been vaccinated against hepatitis B in childhood and adolescence by questionnaire
• Consent to administer 1-2 doses of hepatitis B vaccine according to the assigned group after sharing decision making process
• In good health