• Age 18 to 70;

• HBV infection confirmed by positive HBsAg for \>/= 6 months;

• On HBV-active nucleos(t)ide therapy for \>/= 6 months without change in NRTI in the previous 3 months;

• The following laboratory values within 49 days from study entry (day 0):

• HBV DNA below lower limit of quantification;

• HBsAg \> 10 IU/mL;

• HBs antibody negative;

• Ability and willingness to provide informed consent;

• For participants who can become pregnant (i.e., participants who have not been post-menopausal for at least 24 consecutive months, who have had menses within the preceding 24 months, or who have not undergone surgical sterilization, specifically hysterectomy and/or bilateral oophorectomy or bilateral salpingectomy), negative serum or urine pregnancy test at screening and on day 0 (study entry).

• Participants who can become pregnant must agree to use two methods of contraception.

• Partner sterilization with documentation of azoospermia prior to the participant's entry into the study, and this partner is the sole partner for that participant. The documentation of partner sterility can come from the site personnel's review of medical records or medical history interview provided by the participant or the partner. Self-reported documentation of reproductive potential should be entered in the source documents.

• Participants who can impregnate a partner and who are engaging in sexual activity that could lead to pregnancy must agree to use condoms from 10 days prior to study entry and during study follow up to avoid impregnating a partner who can get pregnant.