A Prospective Observational Study on the Effects of Concomitant Administration of Bacteroides Fragilis and Branched-Chain Amino Acids on HBsAg Clearance
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
The goal of this prospective observational study is to determine the effects of concomitant administration of Bacteroides fragilis and Branched-Chain Amino Acids on hepatitis B virus clearance. The primary question it aims to answer is whether this concomitant administration can promote HBV clearance. The study will observe the HBV clearance rate in chronic hepatitis B patients who receive Bacteroides fragilis and BCAA as a supplement to their routine antiviral therapy. For comparison, researchers will compare the clearance rate in this group to that observed in a control group of chronic hepatitis B patients receiving a standard antiviral regimen based on PegIFNα2b and nucleoside analogs.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• \- chronic hepatitis B patients
Locations
Other Locations
China
The First Affiliated Hospital of Fujian Medical University
RECRUITING
Fuzhou
Contact Information
Primary
JinShui Pan
zdy20221021@gmail.com
0086+059187981658
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 40
Treatments
PegIFNα2b+Nucleoside analog
The patients receive both PegIFNα2b and Nucleoside analog therapy.
PegIFNα2b+Nucleoside analog+Bacteroides fragilis+Branched-Chain Amino Acids
The patients received the concomitant administration of Bacteroides fragilis and Branched-Chain Amino Acids, supplemented to their ongoing combination therapy with PegIFNα2b and Nucleoside analog.
Related Therapeutic Areas
Sponsors
Leads: First Affiliated Hospital of Fujian Medical University