The Impact of Abdominal Wall Closure Technique on Incidence of Incisional Hernia in Kidney Transplantation

Status: Recruiting
Location: See location...
Intervention Type: Other, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

STUDY SUMMARY Incisional hernias, or swellings of the abdominal scar after surgery, remain problematic especially after transplant surgery. This is because they can cause complications, including trapping of bowel or the transplant. This can cause life threatening emergencies but is at the very least unsightly and uncomfortable for the patient. Transplant patients are especially likely to develop hernias because of the diseases causing the renal failure and the drugs that they take to dampen the immune system. There is evidence from other surgery that the stitching methods that are used to close the wounds might decrease the risk of surgical hernias. This is achieved by placing smaller and more numerous sutures (stitches) in the wound to increase the strength of the repair. However, this has never been tested formally in transplant where it may provide significant benefit. We intend to do some initial investigation of whether using the smaller stitches may provide benefit over more traditional methods that are currently being used. We will look at early complications after surgery but also the rate of hernia formation later. We hope to improve outcomes and reduce complications for our transplant patients by doing this. In addition we will collect blood and tissue samples from both live kidney donors and the recipients to microscopically analyse their collagen to identify potential factors which may indicate risk of hernia formation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:

• End-stage renal failure patients

• Aged 18-70yrs

• First transplants or second transplants

• Ability to adequately understand English and consent for study

• BMI\<35 kg/m2)

Locations
Other Locations
United Kingdom
Manchester University NHS Foundation Trust
RECRUITING
Manchester
Contact Information
Primary
Alex Shaw
alex.shaw@mft.nhs.uk
+441617012066
Backup
Angela Summers, PhD
angela.summers@mft.nhs.uk
+441617012066
Time Frame
Start Date: 2020-03-10
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 50
Treatments
Active_comparator: Small Stitch
Small stitch for wound closure
Active_comparator: Large Stitch
Large Stitch for wound closure
Related Therapeutic Areas
Sponsors
Leads: Manchester University NHS Foundation Trust

This content was sourced from clinicaltrials.gov