• Diagnosis of HS for at least 6 months prior to screening visit.

• Mild to moderate HS (Hurley I or II) with the following at both screening and baseline visits:

‣ A total AN count of at least 4, with no draining tunnels AND

⁃ Affecting at least 2 distinct anatomical areas

• Agreement to NOT use topical and systemic antibiotics for treatment of HS during the vehicle-controlled period.

• Agreement to NOT use topical antiseptics, including washes and leave-on products on the areas affected by HS lesions during the vehicle-controlled period and Weeks 16 to 20 of the extension period.

• Further inclusion criteria apply.