Exploration of Brain Functional Networks in Patients With Hidradenitis Suppurativa Using fMRI
The goal of this observational study is to learn whether adults with hidradenitis suppurativa (HS) have changes in resting brain activity and how these changes are related to disease severity, pain, sleep, mood, and quality of life. The study will also examine whether brain activity changes after patients receive biologic or small-molecule treatment as part of their regular medical care. The main questions it aims to answer are: * Are resting brain activity patterns different between people with HS and healthy participants? * Are these brain activity patterns related to HS severity, pain, sleep problems, anxiety, depression, and quality of life? * Do brain activity patterns change after 3 months of routine treatment, and are these changes related to improvement in HS symptoms? Researchers will compare participants with HS with healthy participants of similar age and sex. A subgroup of participants with HS who receive biologic or small-molecule treatment as part of routine clinical care will also be assessed before and after treatment. Participants may: * Complete assessments of HS severity, pain, sleep, mood, and quality of life * Undergo resting-state functional magnetic resonance imaging * Undergo skin ultrasound and routine laboratory testing * Allow photographs of affected skin areas to be taken * Return for follow-up assessments for up to 3 months
⁃ For Participants With Hidradenitis Suppurativa:
• Aged 18 to 45 years.
• Diagnosed with hidradenitis suppurativa according to established clinical diagnostic criteria.
• Able and willing to comply with the study procedures and follow-up assessments.
• Able to provide written informed consent and willing to permit photography of affected skin areas.
• No coexisting systemic lupus erythematosus, dermatomyositis, atopic dermatitis, steroid-dependent dermatitis, or other relevant skin diseases.
• No use of biologic or small-molecule therapy that may affect hidradenitis suppurativa symptoms within 3 months before enrollment.
• Right-handed according to the Edinburgh Handedness Inventory.
⁃ For Healthy Participants:
• Aged 18 to 55 years.
• No hidradenitis suppurativa or other chronic skin disease.
• No chronic pain disorder.
• No major neurological or psychiatric disorder.
• Right-handed according to the Edinburgh Handedness Inventory.
• Able to provide written informed consent and comply with the study procedures.
⁃ For the Longitudinal Treatment Cohort:
• Meets the eligibility criteria for participants with hidradenitis suppurativa.
• Is scheduled to receive biologic or small-molecule therapy for hidradenitis suppurativa as part of routine clinical care, as determined by the treating physician.
• Willing and able to complete assessments before treatment and during 3 months of follow-up.