A Randomized, Open-Label, Dose-Ranging Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Weekly Alirocumab in Adults With Hypercholesterolemia
Status: Recruiting
Location: See all (34) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
This study is researching an experimental drug called alirocumab, referred to as study drug. In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels). The aim of the study is to see how safe and effective alirocumab is when given weekly to adult participants who have hypercholesterolemia. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug once a week * How much study drug is in the blood at different times
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• 1\. Participant has elevated LDL-C level, as defined in the protocol
Locations
United States
Alabama
Pinnacle Research Group
RECRUITING
Anniston
Cullman Clinical Trials
RECRUITING
Cullman
California
Anaheim Clinical Trials
RECRUITING
Anaheim
Cenexel CNS
RECRUITING
Los Alamitos
Diablo Clinical Research - Flourish Research
RECRUITING
Walnut Creek
Florida
Tampa Bay Medical Research
RECRUITING
Clearwater
Southwest General Healthcare Center
RECRUITING
Fort Myers
Precision Clinical Research
RECRUITING
Sunrise
K2 Medical Research The Villages
RECRUITING
The Villages
Georgia
Center for Advanced Research and Education
RECRUITING
Gainesville
Balanced Life Health Care Solutions
RECRUITING
Lawrenceville
Hawaii
East-West Medical Research Institute
RECRUITING
Honolulu
Kentucky
L-MARC Research Center
RECRUITING
Louisville
Louisiana
Tandem Clinical Research
RECRUITING
Marrero
Montana
Mercury Street Medical Group, PLLC
RECRUITING
Butte
North Carolina
Velocity Clinical Research - Durham
RECRUITING
Durham
Accellacare of Wilmington
RECRUITING
Wilmington
Nebraska
Velocity Clinical Research - Omaha
RECRUITING
Omaha
Nevada
Palm Research Center, Mountainview Medical Center
RECRUITING
Las Vegas
Ohio
Ohio Clinical Trials
RECRUITING
Columbus
Oklahoma
AMR Norman
RECRUITING
Norman
Lynn Health Science Institute
RECRUITING
Oklahoma City
Oregon
Velocity Clinical Research, Medford
RECRUITING
Medford
Pennsylvania
Altoona Center for Clinical Research
RECRUITING
Duncansville
South Carolina
Tribe Clinical Research
RECRUITING
Greenville
Coastal Carolina Research Center_North Charleston
RECRUITING
North Charleston
Texas
Velocity Clinical Research Dallas
RECRUITING
Dallas
Valley Institute of Research, Rockwood Medical Clinic
RECRUITING
Fort Worth
Be Well Clinical Studies - Round Rock
RECRUITING
Round Rock
Endeavor Clinical Trials
RECRUITING
San Antonio
Flourish Research - San Antonio Medical Trials
RECRUITING
San Antonio
Consano Clinical Research, LLC
RECRUITING
Shavano Park
Virginia
Charlottesville Medical Research
RECRUITING
Charlottesville
Washington
Rainier Clinical Research Center
RECRUITING
Renton
Contact Information
Primary
Clinical Trials Administrator
clinicaltrials@regeneron.com
844-734-6643
Time Frame
Start Date: 2026-06-17
Estimated Completion Date: 2027-02-23
Participants
Target number of participants: 420
Treatments
Experimental: Arm 1 - Low Dose
Experimental: Arm 2 - Medium Dose
Experimental: Arm 3 - High Dose
Experimental: Arm 4 - Control Dose
Related Therapeutic Areas
Sponsors
Leads: Regeneron Pharmaceuticals