5 Versus 10 Units of Insulin in Hyperkalemia Management: Multi-center, Prospective, Double-blind, Non-inferiority, Randomized Control Trial.
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The goal of this study is to compare 5 units of intravenous Regular insulin to 10 units of intravenous regular insulin in the management of hyperkalemia. We will measure the efficacy of these 2 doses of insulin in reducing hyperkalemia at 2 hours from administration using the main laboratory serum values.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Hyperkalemia patients with lab potassium levels equal to or more than 5.5 mEq/L (≥ 5.5 mEq/L)+.
• Adult: age 18 years or more.
• Agreed to participate in the study.
⁃ If an investigator decides to start anti-hyperkalemia medications based on the VBG/ABG patient can be enrolled but if the main laboratory value is less than 5.5 mEq/L patients will be excluded
Locations
Other Locations
Oman
Sultan Qaboos University hospital
RECRUITING
Seeb
Contact Information
Primary
Adnan Al-Ajmi, MD
r2124@resident.omsb.org
98880381
Backup
Ibrahim Al-Hooti, MD
r2127@resident.omsb.org
92985424
Time Frame
Start Date: 2023-10-01
Estimated Completion Date: 2024-12
Participants
Target number of participants: 336
Treatments
Active_comparator: 5 units of intravenous R insulin
Will receive:~IV Insulin Regular 5 units with Dextrose 50 % 50 ml over 30 minutes. Salbutamol 10 mg Nebulization over 15 minutes.
Active_comparator: 10 units of intravenous R insulin
Will Receive:~IV Insulin Regular 10 units with Dextrose 50 % 50 ml over 30 minutes. Salbutamol 10 mg nebulization over 15 minutes.
Related Therapeutic Areas
Sponsors
Collaborators: Sultan Qaboos University
Leads: Oman Medical Speciality Board