A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Clinical Study to Evaluate the Efficacy and Safety of WS016 in Patients With Hyperkalemia

Status: Recruiting
Location: See all (50) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This clinical trial consists of 2 parts, Part A and Part B. Part A consists of a 2-day randomized, double-blind, placebo-controlled corrective phase (CP) and a 28-day randomized, double-blind, placebo-controlled maintenance phase (MP). Part B (open-label extension, OLE) is an open-label, 11-month extension study carried out in participants who come from Part A and meet certain inclusion criteria.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adults (male or female) aged 18 years and older;

• Participants with a serum potassium concentration \>5.0 mmol/L and ≤6.5 mmol/L (serum potassium concentration will be measured using the i-STAT portable biochemical analyzer in screening period);

• Participants who have negative pregnancy test result at screening and ensure the use of contraception during the trial;

• Participants who understand and voluntarily sign the Informed Consent Form.

Locations
Other Locations
China
Investigator Site 02
RECRUITING
Bengbu
Investigator Site 30
RECRUITING
Changzhou
Investigator Site 45
RECRUITING
Chengdu
Investigator Site 47
RECRUITING
Chengdu
Investigator Site 37
RECRUITING
Chifeng
Investigator Site 48
RECRUITING
Chongqing
Investigator Site 18
RECRUITING
Daqing
Investigator Site 46
RECRUITING
Deyang
Investigator Site 32
RECRUITING
Ganzhou
Investigator Site 07
RECRUITING
Guangzhou
Investigator Site 11
RECRUITING
Guiyang
Investigator Site 12
RECRUITING
Haikou
Investigator Site 24
RECRUITING
Hengyang
Investigator Site 36
RECRUITING
Hohhot
Investigator Site 31
RECRUITING
Huai'an
Investigator Site 21
RECRUITING
Huangshi
Investigator Site 08
RECRUITING
Huizhou
Investigator Site 28
RECRUITING
Jiaxing
Investigator Site 41
RECRUITING
Jinan
Investigator Site 05
RECRUITING
Lanzhou
Investigator Site 33
RECRUITING
Nanchang
Investigator Site 01
RECRUITING
Nanjing
Investigator Site 09
RECRUITING
Nanning
Investigator Site 10
RECRUITING
Nanning
Investigator Site 26
RECRUITING
Nantong
Investigator Site 15
RECRUITING
Nanyang
Investigator Site 16
RECRUITING
Nanyang
Investigator Site 14
RECRUITING
Puyang
Investigator Site 40
RECRUITING
Qingdao
Investigator Site 44
RECRUITING
Shanghai
Investigator Site 34
RECRUITING
Shangrao
Investigator Site 35
RECRUITING
Shenyang
Investigator Site 13
RECRUITING
Shijiazhuang
Investigator Site 20
RECRUITING
Shiyan
Investigator Site 27
RECRUITING
Suzhou
Investigator Site 39
RECRUITING
Tancheng
Investigator Site 50
RECRUITING
Wenzhou
Investigator Site 19
RECRUITING
Wuhan
Investigator Site 22
RECRUITING
Wuhan
Investigator Site 03
RECRUITING
Wuhu
Investigator Site 42
RECRUITING
Xi'an
Investigator Site 43
RECRUITING
Xi'an
Investigator Site 04
RECRUITING
Xiamen
Investigator Site 25
RECRUITING
Xinxiang
Investigator Site 29
RECRUITING
Yangzhou
Investigator Site 38
RECRUITING
Yinchuan
Investigator Site 17
RECRUITING
Yueyang
Investigator Site 06
RECRUITING
Zhanjiang
Investigator Site 23
RECRUITING
Zhuzhou
Investigator Site 49
RECRUITING
Zigong
Contact Information
Primary
Waterstone Medical Center
mpr2024_waterstone@waterstonepharma.com
+86 27 87531661
Time Frame
Start Date: 2024-12-23
Estimated Completion Date: 2026-11
Participants
Target number of participants: 420
Treatments
Experimental: WS016 (corrective phase)
Placebo_comparator: Placebo (corrective phase)
Experimental: WS016 (maintenance phase)
Placebo_comparator: Placebo (maintenance phase)
Experimental: WS016 (open-label extension phase)
Related Therapeutic Areas
Sponsors
Leads: Waterstone Pharmaceutical (Wuhan) Co., LTD.

This content was sourced from clinicaltrials.gov