HOPE in Action Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes
Status: Recruiting
Location: See all (18) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Participant meets local criteria for kidney transplant.
• Participant is able to understand and provide informed consent.
• Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
• Participant is ≥ 18 years old.
• HIV-1 RNA \< 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \> 200 copies/mL.
• Participant is not suffering from significant wasting (e.g. body mass index \<21) thought to be related to HIV disease.
Locations
United States
Alabama
University of Alabama at Birmingham
RECRUITING
Birmingham
California
University of California, Davis
RECRUITING
Sacramento
University of California, San Diego
RECRUITING
San Diego
University of California, San Francisco
RECRUITING
San Francisco
Florida
Mayo Clinic Florida
RECRUITING
Jacksonville
Illinois
Northwestern University
RECRUITING
Chicago
Rush University Medical Center
RECRUITING
Chicago
Louisiana
Ochsner Clinic Foundation
RECRUITING
New Orleans
Massachusetts
Massachusetts General Hospital
RECRUITING
Boston
Maryland
Johns Hopkins University
RECRUITING
Baltimore
Missouri
Washington University St. Louis Barnes Jewish Hospital
RECRUITING
St Louis
New York
Columbia University
RECRUITING
New York
Icahn School of Medicine at Mt. Sinai
RECRUITING
New York
New York University
RECRUITING
New York
Weill Cornell Medical Center
NOT_YET_RECRUITING
New York
Pennsylvania
University of Pennsylvania
RECRUITING
Philadelphia
University of Pittsburgh Medical Center
RECRUITING
Pittsburgh
Texas
Houston Methodist Research Institute
RECRUITING
Houston
Contact Information
Primary
Christine Durand, MD
cdurand2@jhmi.edu
410-614-6702
Time Frame
Start Date: 2024-05-22
Estimated Completion Date: 2029-09
Participants
Target number of participants: 200
Treatments
Experimental: HIV D+/R+
People living with HIV who receive kidneys from deceased donors with HIV
Experimental: HIV D-/R+
People living with HIV who receive kidneys from deceased donors without HIV
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Allergy and Infectious Diseases (NIAID)
Leads: Johns Hopkins University