The Role of Cognitive Biases in the Decision to Request, Offer, Accept and Continue on PrEP From a Health Care Provider and Patient Perspective (Men Who Have Sex With Men)

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality that requires individuals to take a daily tablet to prevent themselves acquiring HIV. In South Africa while this is freely available in the public sector, persistence (that is continuation after initiation) is low amongst vulnerable populations, including men who have sex with men (MSM). This study is a feasibility and acceptability study of a behavioral economics informed intervention to improve persistence amongst MSM newly initiating PrEP in South Africa. The goal of this study is to show that this approach is possible in a routine setting and gather the necessary data for a fully powered effectiveness trial. Study participants will complete a baseline questionnaire and then be randomized to either receive standard of care (control) or to receive the intervention. The intervention package consists of evidence informed reminders, commitment pledges and planning prompts. The intervention package aims to address present bias, optimism bias and salience. The intervention is delivered and the enrollment visit and then through mobile phone reminders / text messages. There is no further in person interaction after the initial interaction. Participants may be contacted for a telephonic enplane questionnaire. Outcome data is obtained from passive followup through routine medical record review with the primary end point being persistence at 3 months.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Healthy Volunteers: f
View:

• Not currently on pre exposure prophylaxis (PrEP); no PrEP within the last 12 months

• Initiating PrEP on the date of enrolment

• Access to a mobile phone

• Willing and able to provide written informed consent in English

Locations
United States
Massachusetts
Boston Univeristy School ofPublic Health, Global Health
NOT_YET_RECRUITING
Boston
Other Locations
South Africa
The Ivan Tom's Centre for Men's Health
RECRUITING
Cape Town
The Aurum POP INN Clinic
RECRUITING
Pretoria
Contact Information
Primary
Lawrence C Long, PhD MCom
lclong@bu.edu
617 358 3122
Time Frame
Start Date: 2025-01-23
Estimated Completion Date: 2026-06
Participants
Target number of participants: 140
Treatments
Experimental: Intervention group
Participants randomized into this group will receive a behavioral economics informed intervention to improve persistence among amongst high risk men newly initiating PrEP in South Africa.
No_intervention: Control group
Usual care for high risk men newly initiating PrEP in South Africa.
Related Therapeutic Areas
Sponsors
Leads: Boston University
Collaborators: National Institute of Mental Health (NIMH)

This content was sourced from clinicaltrials.gov