Use of Unmanned Air Vehicles (Medical Drones) to Overcome Geographical Barriers to Delivery of Anti-Retrovical Samples: A Cluster Randomised Trial in Kalangala District, Uganda

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if the intervention of delivery of antiretroviral drugs by medical drones can improve virological suppression in a fisherfolk community population living with HIV in the islands of Kalangala District, Uganda. The main question it aims to answer is: Can delivery of anti-retroviral therapy (ART) by unmanned aerial vehicles (medical drones) to people living with HIV (PLHIV) improve virological outcomes compared to the standard of care (SOC) in an underserved population? Primary hypothesis: The investigators hypothesize that using drones will increase viral suppression in those receiving the intervention as compared to the control or outcome measure one-will be the proportion of PLHIV with undetectable HIV viral load in the intervention (drones) versus SOC arm at 12 months. If there is a comparison group: Researchers will compare \[Medical Drones delivery group\] to see total cost of 12 months medication delivery to people living with HIV (PLHIV) in the intervention as compared to standard of care (SOC) arm. Proportion PLHIV with an undetectable viral load at 6, 18 and 24 months in intervention Rates of retention in care of PLHIV at 6,12, 18 and 24 months in intervention as compared to SOC arm * Participants will be seen every 6 months for 24 months * They will have blood draws for viral load tests * They will complete interviewer administered questionnaires * The intervention is last-mile delivery of ART by drones to landing sites

Eligibility
Participation Requirements
Sex: All
Minimum Age: 15
Healthy Volunteers: f
View:

• Adult (\>18 years) living with HIV

• Emancipated minor (15-17 years) who is living with HIV

• Receiving antiretroviral therapy in Kalangala District

• Be a resident in Kalangala district for at least the preceding 6-12 months

• Willing to stay for a minimum next 24 months

• Willing to disclose HIV status to an expert peer or village health team member.

• Willing to join discentralised Service Delivery model groups

Locations
Other Locations
Uganda
Bwendero Health Centre
RECRUITING
Kalangala
Mugoye health Centre III
RECRUITING
Kalangala
Contact Information
Primary
Rosalind Principal Investigator, MBBS, MA Hons, MRCP, Ph.D
rratanshi@idi.co.ug
+256312211422
Backup
Agnes Bwanika Naggirinya, MBChB, MSC, MMed
anaggirinya@idi.co.ug
+256 312211422
Time Frame
Start Date: 2025-03-18
Estimated Completion Date: 2027-12-15
Participants
Target number of participants: 1086
Treatments
Experimental: Intervention Arm
Delivery of ART by fixed wing drones to landing sites
Active_comparator: Control arm
Usual ART delivery to landing sites
Related Therapeutic Areas
Sponsors
Collaborators: Medical Research Council, United Kingdom Research and Innovation
Leads: Makerere University

This content was sourced from clinicaltrials.gov