Pilot Study Evaluating the Benefits of Music Therapy Combined With Conventional Treatment on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)
The study is an open-label clinical trial evaluating whether music therapy combined with conventional management reduces irritability and impulsivity in 15 patients with early-stage Huntington's disease. This pilot study aims to show the interest of alternative non-pharmacological measures such as a digital music therapy tool, adapted to an audience of Huntington's patients, to help manage the psychobehavioral symptoms frequently observed in this affection, and to avoid breakdowns due to caregiver exhaustion.
• Age \>= 18 years
• Huntington disease genetically confirmed by the presence of at least 35 repeats of the CAG triplet in exon 1 of the HTT gene
• UHDRS (Unified Huntington's disease Rating Scale) score \<= 5 with a diagnostic confidence score =4
• Absence of significant cognitive impairment MoCA \>=24
• Stable drug therapy in the 28 days prior inclusion and during the study
• Without legal tutors or subordination
• Affiliated to a health insurance system as required by the French law on biomedical research
• Written informed consent for participation in the study