Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule，A Prospective Multicentre Randomized Controlled Trial
The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A. treated with chemotherapy immediately, B. follow up until hCG level met FIGO diagnostic criteria of GTN (B1) or hCG level declined to normal spontaneously (B2). Lung nodule \<1.0cm will directly treated as group C
⁃ Eligible patients have to meet all of the following criteria:
• Pathologically confirmed HM.
• The lung nodules are detected by lung CT and metastatic lesions could not be excluded (before or after the suction dilation and curettage).
• The hCG level does not meet FIGO diagnostic criteria (2018) of GTN.
• The patients are willing to compliant with the study protocol and be followed up at regular intervals.
• The patients agree to sign an informed consent form.