The Role of Proprotein-convertase-subtilisin/Kexin-type 9 in Kidney Damage in Nephrotic Syndrom

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Nephrotic syndrome (NS) is characterized by gross proteinuria (\>3.5 g/day), hypoalbuminaemia, edema and often hyperlipidemia. Hyperlipidemia is correlated with increased morbidity and mortality. The study aim is to investigate the role of the protein convertase subtilisin/kexin type 9 (PCSK9) in hyperlipidemia of NS, which has been suggested to play an important role. This is done by testing the following hypotheses: 1. PCSK9 is increased in patients with NS and hyperlipidemia compared to kidney-healthy controls 2. The level of PCSK9 in plasma correlates to the degree of proteinuria. 3. PCSK9 i increased in the kidney tissue of patients with NS The study will compare plasma levels of PCSK9 in correlation with degree of protein in the urine between test persons with NS and kidney healthy controls. Furthermore the investigators will study the the degree of PCSK9 in the kidney in biopsies obtained from test persons with nephrotic syndrome and test persons without proteinuria.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• 18 years old

• Patients admitted to the Medical Department and/or the Medical Emergency Department, Kolding Sygehus.

Locations
Other Locations
Denmark
Kolding Sygehus, Lillebælt Hospital
RECRUITING
Kolding
Contact Information
Primary
Rikke Z Langkilde, MD, phd
rikke.zachar.langkilde@rsyd.dk
004576362554
Backup
Anne D Thuesen, MD, phd
Anne.Daugaard.Thuesen2@rsyd.dk
004576360555
Time Frame
Start Date: 2023-06-01
Estimated Completion Date: 2028-07-30
Participants
Target number of participants: 75
Treatments
Nephrotic syndrome
Patients with nephrotic syndrome (n=32). Blood samples and 24 hour urine samples will be obtained an all participants. Kidney biopsy will be used from 11 test persons, whos been subjected to kidney biopsy unrelated to the research project.~3
Kidney healthy controls
Patient with normal kidney function and no proteinuria (n=32). Blood samples and 24 hour urine samples will be obtained an all participants.
Kidney biopsy control
Patients without proteinuria who is subjected to kidney biopsy regardless of the research project.
Related Therapeutic Areas
Sponsors
Leads: Kolding Sygehus
Collaborators: Odense University Hospital, Vejle Hospital

This content was sourced from clinicaltrials.gov