Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify responders who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 39
Healthy Volunteers: t
View:
• age ≥ 18 and \< 40 years
• BMI ≥ 18.5 and \< 25.0 kg/m2
• baseline serum LDL-c \< 150 mg/dL (\< 3.9 mmol/L)
• baseline serum TG \< 100 mg/dL (\< 1.1 mmol/L)
• HbA1c ≤ 5.6%.
Locations
United States
Missouri
Washington University School of Medicine
RECRUITING
St Louis
Contact Information
Primary
Nikki Plassmeyer, M.A., R.D.N., L.D.
nikkip@wustl.edu
(314) 362-0590
Backup
Max C Petersen, M.D., Ph.D.
max.p@wustl.edu
314-362-8450
Time Frame
Start Date: 2025-02-24
Estimated Completion Date: 2030-11-30
Participants
Target number of participants: 100
Treatments
Experimental: A
Arm A will complete the Ketogenic Diet intervention first, followed by the Control Diet intervention after a 4-week washout period.
Experimental: B
Arm B will complete the Control Diet intervention first, followed by the Ketogenic Diet intervention after a 4-week washout period.
Related Therapeutic Areas
Sponsors
Leads: Washington University School of Medicine