Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function Can 18F-PET Replace Bone Histomorphometry
The aim of the study is to 1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively. 2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes 3. To investigate if non-oxidized PTH reflects bone turnover
• ≥ 18 years
⁃ estimated Glomerular Filtration Rate (eGFR) ≤ 20 ml/min/1,73m2
⁃ PTH \< 150 pg/ml or PTH \> 300 pg/ml
• ≥ 18 years
⁃ eGFR \>= 60 ml/min
⁃ under examination for c prostata
⁃ Prostatic Specific Antigen (PSA) total \<40 µg/l
‣ Exclusion:
⁃ Former kidney disease
⁃ ionized calcium or PTH outside normal range
⁃ Known metabolic bone disease
⁃ treatment with anticoagulants
⁃ Disturbed thrombosis and hemostasis