Effects of Combination Medical Therapy Followed by Balloon Pulmonary Angioplasty on Right Ventricular-PA Coupling and Hemodynamics in Chronic Thromboembolic Pulmonary Hypertension
The main goal of this study is to determine the effects of combination medical therapy (Riociguat and Macitentan) and balloon pulmonary angioplasty (BPA) on hemodynamics and right ventricular (RV) function (including advanced assessments of RV-pulmonary artery (PA) coupling from invasive hemodynamics) in participants with inoperable or post-PTE residual CTEPH.
⁃ Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial:
• Age ≥ 18 years' old
• Diagnosis of CTEPH
• Not a candidate for PTE
• Candidate for BPA based on suitable anatomy and disease burden
• Treatment-naïve (no CTEPH or pulmonary arterial hypertension (PAH)-specific medical therapies) with plans for initiation of CTEPH/PAH-specific medical therapy and treatment with BPA.
• Willing and able to give informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed).