Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health: A Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The investigators long-term goal is to better understand novel interventions to promote cardiovascular health in humans. The goal of the proposed research is to investigate whether there is sex-specificity in the effects of dietary capsaicin on mechanisms regulating nitric oxide (NO) bioavailability, its effect on key markers of cardiovascular (CV) health, including BP, macro- and microvascular function, and arterial stiffness. This knowledge will provide critical insight into the effects of dietary capsaicin on CV health and will guide future trials.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• relatively healthy (other than elevated blood pressure) non-smoking men and women over the age of 18 from the local community
Locations
United States
New York
Skidmore College
RECRUITING
Saratoga Springs
Contact Information
Primary
Stephen Ives, PhD
sives@skidmore.edu
5185808366
Time Frame
Start Date: 2024-07-08
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 80
Treatments
Experimental: Dietary Capsaicin
Over-the-counter dose of 2 x 440 mg capsules (880 mg, Capsicum Pepper Blend, Daily Manufacturing, Rockwell, North Carolina, USA)
Placebo_comparator: Placebo
The placebo will be 2 x 400-500 mg fiber (800 mg psyllium husk) capsules which were chosen to be of similar appearance (size, coloration, and texture).
Related Therapeutic Areas
Sponsors
Collaborators: American Heart Association
Leads: Skidmore College