Theobromine Consumption From Cocoa and Cardiovascular Risk Factors in Humans: Evidence for Health Claims

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to examine whether consumption of dark chocolate affects blood pressure and a cardiovascular risk factor called trimethylamine N-oxide in Thai male participants with hypertension. The main questions it aims to answer are: Can consumption of dark chocolate lower blood pressure? Can consumption of dark chocolate lower blood trimethylamine N-oxide? Researchers will compare dark chocolate to white chocolate to see if the effects are due to theobromine (a key bioactive compound in dark chocolate). Participants will consume either 100 g 72% dark chocolate bar or 80 g white chocolate bar daily for 14 days, rest for 7 days, and then switch to the other type of chocolate.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 35
Maximum Age: 70
Healthy Volunteers: f
View:

• Male

• Age between 35 to 70 years

• BMI less than 30 kg/m\^2

• Systolic blood pressure between 130 to 159 mmHg or Diastolic blood pressure between 85 to 99 mmHg.

• Do not smoke.

Locations
Other Locations
Thailand
Research Institute for Health Sciences, Chiang Mai University
RECRUITING
Mueang
Contact Information
Primary
Kongsak - Boonyapranai, Doctoral degree
Kongsak.b@cmu.ac.th
+66-92-271-721
Backup
Siraphat Taesuwan, Doctoral degree
siraphat.t@cmu.ac.th
+66-89-735-0953
Time Frame
Start Date: 2025-02-15
Estimated Completion Date: 2025-09
Participants
Target number of participants: 42
Treatments
Experimental: Dark chocolate
100 g/day of dark chocolate
Placebo_comparator: White chocolate
80 g/day of white chocolate
Related Therapeutic Areas
Sponsors
Leads: Chiang Mai University

This content was sourced from clinicaltrials.gov