A Randomized, Double-blind, Placebo-controlled, Multicenter, 12 Months Treatment Duration, Dose Finding Study, to Evaluate Efficacy, Safety and Pharmacodynamics of QCZ484 in Mild to Moderate Hypertensive Patients
Status: Recruiting
Location: See all (83) locations...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The purpose of this study is to evaluate the efficacy, safety and tolerability of QCZ484 or placebo, given subcutaneously, every 6 months, at different dose levels in patients with mild to moderate hypertension
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Signed informed consent.
• Males or females aged 18 to 75 years.
• Diagnosis of hypertension.
• Hypertension treatment naive or on maximum 2 anti-HTN medications and able to undergo washout for 4 weeks.
• Mean sitting SBP ≥140 mmHg measured by OBPM and mean 24 hr SBP ≥130 mmHg and \<160 mmHg measured by ABPM.
• Participants able to understand and comply with study procedures.
Locations
United States
Alabama
SEC Clinical Research LLC
RECRUITING
Andalusia
UAB St Vincents
RECRUITING
Birmingham
Longwood Research
RECRUITING
Huntsville
The Center for Clinical Trials
RECRUITING
Saraland
Arizona
Elite Clinical Studies
RECRUITING
Phoenix
Synexus Clinical Research US Inc
RECRUITING
Tucson
California
NICRs Research Center
RECRUITING
Garden Grove
Valiance Clinical Research
RECRUITING
Huntington Park
Downtown L A Research Center Inc
RECRUITING
Los Angeles
Clinical Trials Research Sacramento
ACTIVE_NOT_RECRUITING
Sacramento
Encompass Clinical Research
RECRUITING
Spring Valley
Florida
Clinical Research of Brandon LLC
RECRUITING
Brandon
ALL Medical Research LLC
RECRUITING
Cooper City
National Research Institute
RECRUITING
Hialeah
Cen Exel RCA
RECRUITING
Hollywood
East Coast Institute for Research
RECRUITING
Jacksonville
Entrust Clinical Research
RECRUITING
Miami
Inpatient Research Clinical LLC
RECRUITING
Miami Lakes
Inpatient Research Clinical LLC
RECRUITING
Miami Lakes
Suncoast Clinical Research
RECRUITING
New Port Richey
Renstar Medical Research
RECRUITING
Ocala
American Research Centers of FL
RECRUITING
Pembroke Pines
Cen Exel FCR
RECRUITING
Tampa
Cardiology Partners Clinical Research Institute
RECRUITING
Wellington
Georgia
Centricity Research
RECRUITING
Columbus
Javara Research
RECRUITING
Fayetteville
Javara Research
RECRUITING
Fayetteville
Velocity Clinical Research
RECRUITING
Savannah
Iowa
Velocity Clin Research Sioux City
RECRUITING
Sioux City
Idaho
Solaris Clinical Research
RECRUITING
Meridian
Illinois
Cedar Crosse Research Ct
RECRUITING
Chicago
Eagle Clinical Research
RECRUITING
Chicago
Indiana
Synexus Clinical Research US
RECRUITING
Evansville
Kansas
Alliance for Multispecialty Research
RECRUITING
Wichita
Louisiana
Velocity Clinical Res Baton Rouge
RECRUITING
Baton Rouge
Southern Clin Research Clinic
RECRUITING
Zachary
Maryland
Ascension Saint Agnes Heart Care
RECRUITING
Baltimore
Anderson Medical Research
RECRUITING
Ft. Washington
Capitol Cardiology Associates
RECRUITING
Lanham
Michigan
AA Medical Research Center
RECRUITING
Flint
Oakland Medical Research Center
RECRUITING
Troy
Trinity Health Michigan Heart
RECRUITING
Ypsilanti
Minnesota
Synexus Clinical Research US Inc
RECRUITING
Richfield
Missouri
Healthcare Research Network II LLC
RECRUITING
Hazelwood
Jefferson City Medical Group
RECRUITING
Jefferson City
Clin Rsrch Consult a JCCT Company
RECRUITING
Kansas City
Mississippi
David M Headley Clinic
WITHDRAWN
Port Gibson
North Carolina
Monroe Biomedical Research
RECRUITING
Monroe
Burke Primary Care
RECRUITING
Morganton
Accellacare of Rocky Mount
RECRUITING
Rocky Mount
Accellacare of Salisbury
RECRUITING
Salisbury
Nebraska
Velocity Clin at Pioneer Heart Inst
RECRUITING
Lincoln
New Jersey
CenExel HRI
RECRUITING
Berlin
Nevada
AMR Las Vegas
RECRUITING
Las Vegas
New York
Velocity Clinical Research
RECRUITING
Binghamton
Ohio
CR Services Acquisition US
RECRUITING
Columbus
Oklahoma
Conrad Clinical Research
RECRUITING
Edmond
Oregon
Velocity Clinical Research Medford
RECRUITING
Medford
Pennsylvania
TCV Clinical Studies
RECRUITING
Linwood
South Carolina
Velocity Clinical Research
RECRUITING
Union
Tennessee
Clinical Neuroscience Solutions Inc
RECRUITING
Memphis
Texas
Velocity Clinical Research Austin
RECRUITING
Austin
North Hills Medical Research Inc
RECRUITING
Bedford
Synergy Group Medical LLC
RECRUITING
Houston
Biopharma Informatic
RECRUITING
Katy
Synergy Groups Medical LLC
RECRUITING
Missouri City
Clinical Trials of Texas
RECRUITING
San Antonio
Sun Research Institute
RECRUITING
San Antonio
Utah
AMR Layton
RECRUITING
Layton
Virginia
Manassas Clinical Research Center
RECRUITING
Manassas
Dominion Medical Associates
RECRUITING
Richmond
Centricity Research Suffolk Fam Med
RECRUITING
Suffolk
Washington
MultiCare Ins Research Innovation
RECRUITING
Puyallup
Velocity Clinical Research Spokane
RECRUITING
Spokane
Other Locations
Japan
Novartis Investigative Site
RECRUITING
Chuo Ku
Novartis Investigative Site
RECRUITING
Chuo Ku
Novartis Investigative Site
RECRUITING
Chuo-ku
Novartis Investigative Site
RECRUITING
Shinjuku Ku
Novartis Investigative Site
RECRUITING
Suita
Singapore
Novartis Investigative Site
RECRUITING
Singapore
Novartis Investigative Site
RECRUITING
Singapore
Novartis Investigative Site
RECRUITING
Singapore
Novartis Investigative Site
RECRUITING
Singapore
Contact Information
Primary
Novartis Pharmaceuticals
novartis.email@novartis.com
1-888-669-6682
Backup
Novartis Pharmaceuticals
+41613241111
Time Frame
Start Date: 2025-03-26
Estimated Completion Date: 2028-04-05
Participants
Target number of participants: 380
Treatments
Placebo_comparator: Placebo Control
Placebo
Experimental: QCZ484 Dose 1
QCZ484 Dose 1 solution for injection
Experimental: QCZ484 Dose 2
QCZ484 Dose 2 solution for injection
Experimental: QCZ484 Dose 3
QCZ484 Dose 3 solution for injection
Experimental: QCZ484 Dose 4
QCZ484 Dose 4 solution for injection
Experimental: QCZ484 Dose 5
QCZ484 Dose 5 solution for injection
Related Therapeutic Areas
Sponsors
Leads: Novartis Pharmaceuticals