Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will measure aerobic capacity using a cardiopulmonary exercise test (CPET) using indirect gas-exchange to derive subsequent exercise intensity and maximal oxygen uptake. The investigators will evaluate different measures of vascular function (Pulse-wave velocity, Flow-mediated slowing, microvascular function) before and after each condition. The study will involve two groups of participants: healthy individuals and prehypertensive individuals. The investigators aim to establish the reliability and validity of less-established methods of vascular function assessment (flow-mediated slowing and microvascular function) against established measures (pulse-wave velocity). The acute response of vascular function to different exercise intensities has not yet been thoroughly researched using the aforementioned measures in individuals with similar characteristics to the proposed study cohort.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:

⁃ Normotensive participants inclusion criteria:

• 18 - 50 years of age, BMI \< 30, blood pressure (BP) within the optimal range according to the latest ESH guidelines (\< 120 mmHg systolic and/or \< 80 mmHg diastolic BP)

• Sedentary or low active according to the Global Physical Activity Questionnaire (GPAQ) (Armstrong \& Bull, 2006; Lim et al., 2012)

• No prescribed medication and absence of chronic diseases

• 18 - 50 years of age, BMI \< 30

• Diagnosed prehypertension by a clinican from the Hypertension clinic, University clinical centre of Ljubljana using established criteria

• Sedentary or low or moderately active according to the Global Physical Activity Questionnaire (GPAQ)

• No prescribed medication and absence of chronic diseases

Locations
Other Locations
Slovenia
University of Ljubljana, Faculty of sport
RECRUITING
Ljubljana
Contact Information
Primary
Armin H Paravlic, PhD
armin.paravlic@fsp.uni-lj.si
+386015207840
Time Frame
Start Date: 2025-06-24
Estimated Completion Date: 2026-06
Participants
Target number of participants: 45
Treatments
Placebo_comparator: Normotensive
Normotensives with ambulatory blood pressure measurements within the optimal range according to the 2023 ESH guidelines
Active_comparator: Prehypertensive
Prehypertensives with blood pressure within 120-139 mmHg systolic and/or 80-89 diastolic.
Related Therapeutic Areas
Sponsors
Leads: University of Ljubljana

This content was sourced from clinicaltrials.gov