Thyroid Function and Structure in Klinefelter Syndrome (THINKS)
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 1
Maximum Age: 80
Healthy Volunteers: f
View:
• Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis;
• Availability of thyroid function test results (TSH, fT3, and fT4) and/or thyroid US imaging;
• Availability of concurrent clinical data.
Locations
Other Locations
Italy
'Sapienza' University of Rome
RECRUITING
Roma
Contact Information
Primary
Andrea M Isidori, MD, PhD
andrea.isidori@uniroma1.it
0039649970711
Time Frame
Start Date: 2007-05-11
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 600
Treatments
Klinefelter syndrome
Males affected by 47,XXY non-mosaic Klinefelter syndrome. Subgroups according to pubertal stage: pre-pubertal, pubertal and adults. Subgroups according to gonadal status: eugonadal, hypogonadal and receiving testosterone replacement therapy (TRT).
Healthy controls
Euthyroid, age- and pubertal stage-matched males Subgroups according to pubertal stage: pre-pubertal, pubertal and adults.
Chronic lymphocytic thyroiditis
Adult males affected by chronic lymphocytic thyroiditis
Related Therapeutic Areas
Sponsors
Leads: University of Roma La Sapienza