The COHIR Multi-center Study - a Non-interventional, Prospective, Multi-center Investigation With Exploratory Data Analysis to Assess the Proportion of Patients With Hypophosphatasia Presenting at the Department of Rheumatology and Establishment of an Algorithm to HPP Diagnosis.
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Written informed consent
• Age \> 18 years
• Clinical suspicion of hypophosphatasia
• Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening
Locations
Other Locations
Germany
Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn
RECRUITING
Bonn
Contact Information
Primary
Valentin S. Schäfer, Univ.-Prof. Dr. med. MUDr.
rheumatologie@ukbonn.de
+49 228 287-17000
Backup
Claus-Jürgen Bauer, MD
rheumatologie@ukbonn.de
+49 228 287-17000
Time Frame
Start Date: 2024-08-25
Estimated Completion Date: 2027-09
Participants
Target number of participants: 720
Treatments
Persistant hypophosphatasemia
Transient hypophosphatasemia (Control group without hypophosphatasia)
Related Therapeutic Areas
Sponsors
Leads: University of Bonn