Interrater Variability for the Identification of Anesthetic-induced Burst Suppression EEG

Status: Unknown
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Burst suppression describes a specific EEG pattern that can generally indicate a too deep general anesthesia. The pathophysiology of anesthetic-induced Burst Suppression may be distinctly different from the pathophysiology of Burst Suppression from other medical causes (e.g., coma, hypothermia, intoxication). Definition criteria of neurologic societies cannot be applied to the classification of Burst Suppression during general anesthesia without adaptation. The lack of a clear definition complicates structured research on anesthetic-induced Burst Suppression EEG in the perioperative setting because of subjective bias. Therefore, a unified agreement on what anesthesia-induced Burst Suppression looks like is crucial to conduct the best possible research. The aim of this study is to formulate the basis for a clear definition of burst suppression EEG that may help to truly understand the significance of this EEG pattern and its relationship to proposed postoperative outcomes such as postoperative delirium, longterm postoperative neurocognitive disorders (PNDs) or increased mortality.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:

• leading international experts in the field of intraoperative EEG analysis

Locations
Other Locations
Germany
Klinikum rechts der Isar - Klinik für Anästhesiologie und Intensivmedizin
Munich
Time Frame
Start Date: 2022-08-10
Completion Date: 2023-04-01
Participants
Target number of participants: 40
Treatments
Other: MATLAB-based interface, showing 50 EEG traces
A software environment (MATLAB) was developed, that allows the international experts to access the data set and score the traces pseudonymously. This MATLAB-based interface shows 50 EEG traces. A representative dataset was composed, consisting of definite Burst Suppression patterns (positive control), intraoperative EEG without Burst Suppression patterns (negative control), and patterns indicating different manifestations of a possible Burst Suppression-like pattern.
Related Therapeutic Areas
Sponsors
Leads: Technical University of Munich

This content was sourced from clinicaltrials.gov